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Endocannabinoids control spasticity in a multiple sclerosis model.

Abstract:

Spasticity is a complicating sign in multiple sclerosis that also develops in a model of chronic relapsing experimental autoimmune encephalomyelitis (CREAE) in mice. In areas associated with nerve damage, increased levels of the endocannabinoids, anandamide (arachidonoylethanolamide, AEA) and 2-arachidonoyl glycerol (2-AG), and of the AEA congener, palmitoylethanolamide (PEA), were detected here, whereas comparable levels of these compounds were found in normal and non-spastic CREAE mice. Whi...

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Publication status:
Published

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Publisher copy:
10.1096/fj.00-0399fje

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Sub department:
Institute of Biomedical Engineering
Role:
Author
Journal:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology More from this journal
Volume:
15
Issue:
2
Pages:
300-302
Publication date:
2001-02-01
DOI:
EISSN:
1530-6860
ISSN:
0892-6638

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