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Selective regulation of cytokine induction by adenoviral gene transfer of IkappaBalpha into human macrophages: lipopolysaccharide-induced, but not zymosan-induced, proinflammatory cytokines are inhibited, but IL-10 is nuclear factor-kappaB independent.

Abstract:

Macrophages are the major cytokine producers in chronic inflammatory diseases, but the biochemical pathways regulating cytokine production are poorly understood. This is because genetic tools to dissect signaling pathways cannot be used in macrophages because of difficulties in transfection. We have developed an adenoviral technique to achieve high efficiency gene delivery into macrophages and recently showed that spontaneous TNF-alpha production in rheumatoid arthritis joint cells, chiefly f...

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Publication status:
Published

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Authors


Bondeson, J More by this author
Browne, KA More by this author
Brennan, FM More by this author
Foxwell, BM More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
162
Issue:
5
Pages:
2939-2945
Publication date:
1999-03-05
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:62d1471d-fb33-4ba0-a48f-68213c20212e
Source identifiers:
481584
Local pid:
pubs:481584

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