- Abstract:
-
Macrophages are the major cytokine producers in chronic inflammatory diseases, but the biochemical pathways regulating cytokine production are poorly understood. This is because genetic tools to dissect signaling pathways cannot be used in macrophages because of difficulties in transfection. We have developed an adenoviral technique to achieve high efficiency gene delivery into macrophages and recently showed that spontaneous TNF-alpha production in rheumatoid arthritis joint cells, chiefly f...
Expand abstract - Publication status:
- Published
- Journal:
- Journal of immunology (Baltimore, Md. : 1950)
- Volume:
- 162
- Issue:
- 5
- Pages:
- 2939-2945
- Publication date:
- 1999-03-05
- EISSN:
-
1550-6606
- ISSN:
-
0022-1767
- URN:
-
uuid:62d1471d-fb33-4ba0-a48f-68213c20212e
- Source identifiers:
-
481584
- Local pid:
- pubs:481584
- Copyright date:
- 1999
Journal article
Selective regulation of cytokine induction by adenoviral gene transfer of IkappaBalpha into human macrophages: lipopolysaccharide-induced, but not zymosan-induced, proinflammatory cytokines are inhibited, but IL-10 is nuclear factor-kappaB independent.
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