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Genome-Wide Association Analysis of Imputed Rare Variants: Application to Seven Common Complex Diseases

Abstract:

Genome-wide association studies have been successful in identifying loci contributing effects to a range of complex human traits. The majority of reproducible associations within these loci are with common variants, each of modest effect, which together explain only a small proportion of heritability. It has been suggested that much of the unexplained genetic component of complex traits can thus be attributed to rare variation. However, genome-wide association study genotyping chips have been...

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Publisher copy:
10.1002/gepi.21675
Journal:
Genetic Epidemiology More from this journal
Volume:
36
Issue:
8
Pages:
785-796
Publication date:
2012-12-01
DOI:
EISSN:
1098-2272
ISSN:
0741-0395
Language:
English
Keywords:
Pubs id:
pubs:366745
UUID:
uuid:62b2213c-afd3-4b9c-b78c-e1421f8d7f2c
Local pid:
pubs:366745
Source identifiers:
366745
Deposit date:
2013-11-16

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