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Journal article

Analysis of shared heritability in common disorders of the brain

Abstract:

Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and fr...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1126/science.aap8757

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Role:
Author
ORCID:
0000-0002-0073-4675
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Role:
Author
ORCID:
0000-0003-3864-9828
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Role:
Author
ORCID:
0000-0001-8422-6530
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Publisher:
American Association for the Advancement of Science Publisher's website
Journal:
Science Journal website
Volume:
360
Issue:
6395
Pages:
eaap8757
Publication date:
2018-06-22
Acceptance date:
2018-04-24
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
Pubs id:
pubs:859158
URN:
uri:629cd1c3-e53f-4ef8-a222-6ee278991777
UUID:
uuid:629cd1c3-e53f-4ef8-a222-6ee278991777
Local pid:
pubs:859158

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