Journal article icon

Journal article

Synthesis and biological characterisation of novel N-alkyl-deoxynojirimycin alpha-glucosidase inhibitors.

Abstract:

The N-alkylated deoxynojirimycin compound, N-(6'-(4''-azido-2''-nitrophenylamino)hexyl)-1-deoxynojirimycin (6) was synthesised as a potential photoaffinity probe for endoplasmic reticulum (ER) alpha-glucosidases I and II. Surprisingly this compound was a highly potent inhibitor of alpha-glucosidase I (IC(50), 17 nM) in an in vitro assay and proved equally effective at inhibiting cellular ER glucosidases, as determined by a free oligosaccharide (FOS) analysis. A modest library of compounds was...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1002/cbic.200900025

Authors


Expand authors...
Journal:
Chembiochem : a European journal of chemical biology
Volume:
10
Issue:
6
Pages:
1101-1105
Publication date:
2009-04-05
DOI:
EISSN:
1439-7633
ISSN:
1439-4227
URN:
uuid:624f9539-b073-4d8c-a9a5-171807fecf4d
Source identifiers:
41134
Local pid:
pubs:41134

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP