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NEK1 kinase domain structure and its dynamic protein interactome after exposure to Cisplatin

Abstract:

NEK family kinases are serine/threonine kinases that have been functionally implicated in the regulation of the disjunction of the centrosome, the assembly of the mitotic spindle, the function of the primary cilium and the DNA damage response. NEK1 shows pleiotropic functions and has been found to be mutated in cancer cells, ciliopathies such as the polycystic kidney disease, as well as in the genetic diseases short-rib thoracic dysplasia, Mohr-syndrome and amyotrophic lateral sclerosis. NEK1...

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Publication status:
Published
Peer review status:
Peer reviewed

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Authors


More from this funder
Name:
Fundação de Amparo à Pesquisa do Estado São Paulo
Grant:
2010/51730-0
More from this funder
Name:
Structural Genomics Consortium
Funding agency for:
Knapp, S
Elkins, J
More from this funder
Name:
Conselho Nacional de Pesquisa e Desenvolvimento
More from this funder
Name:
Centro Nacional de Pesquisa em Energia e Materiais
Publisher:
Springer Nature
Journal:
Scientific Reports More from this journal
Volume:
7
Issue:
1
Article number:
5445
Publication date:
2017-07-14
Acceptance date:
2017-06-02
DOI:
ISSN:
2045-2322
Language:
English
Keywords:
Pubs id:
pubs:709552
UUID:
uuid:62404c50-2e1b-4567-beee-b93f771f5a72
Local pid:
pubs:709552
Source identifiers:
709552
Deposit date:
2017-07-31

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