Journal article
NEK1 kinase domain structure and its dynamic protein interactome after exposure to Cisplatin
- Abstract:
-
NEK family kinases are serine/threonine kinases that have been functionally implicated in the regulation of the disjunction of the centrosome, the assembly of the mitotic spindle, the function of the primary cilium and the DNA damage response. NEK1 shows pleiotropic functions and has been found to be mutated in cancer cells, ciliopathies such as the polycystic kidney disease, as well as in the genetic diseases short-rib thoracic dysplasia, Mohr-syndrome and amyotrophic lateral sclerosis. NEK1...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Conselho Nacional de Pesquisa e Desenvolvimento
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Centro Nacional de Pesquisa em Energia e Materiais
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Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Scientific Reports Journal website
- Volume:
- 7
- Issue:
- 1
- Article number:
- 5445
- Publication date:
- 2017-07-14
- Acceptance date:
- 2017-06-02
- DOI:
- ISSN:
-
2045-2322
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:709552
- UUID:
-
uuid:62404c50-2e1b-4567-beee-b93f771f5a72
- Local pid:
- pubs:709552
- Source identifiers:
-
709552
- Deposit date:
- 2017-07-31
Terms of use
- Copyright holder:
- Melo-Hanchuk et al
- Copyright date:
- 2017
- Notes:
- This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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