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Journal article

The IBD2 locus shows linkage heterogeneity between ulcerative colitis and Crohn disease.

Abstract:

The IBD2 locus on chromosome 12 has been linked to both Crohn disease (CD) and ulcerative colitis (UC) but has not been detected in some CD-dominated data sets. In the present study, we genotyped 581 relative pairs with inflammatory bowel disease (252 from CD-only families, 138 from UC-only families, and 191 from mixed families containing cases of both CD and UC), using 12 markers spanning the IBD2 locus. A GENEHUNTER-PLUS multipoint LOD score of 3.91 was detected for pairs from UC-only famil...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1086/316905

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
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Publisher:
Cell Press Publisher's website
Journal:
American journal of human genetics Journal website
Volume:
67
Issue:
6
Pages:
1605-1610
Publication date:
2000-12-01
DOI:
EISSN:
1537-6605
ISSN:
0002-9297
Source identifiers:
135318

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