The IBD2 locus shows linkage heterogeneity between ulcerative colitis and Crohn disease.
The IBD2 locus on chromosome 12 has been linked to both Crohn disease (CD) and ulcerative colitis (UC) but has not been detected in some CD-dominated data sets. In the present study, we genotyped 581 relative pairs with inflammatory bowel disease (252 from CD-only families, 138 from UC-only families, and 191 from mixed families containing cases of both CD and UC), using 12 markers spanning the IBD2 locus. A GENEHUNTER-PLUS multipoint LOD score of 3.91 was detected for pairs from UC-only famil...Expand abstract
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- Copyright © 2001 by The American Society of Human Genetics. Under an Elsevier user license.
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