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Journal article

Membrane nanoclusters of FcγRI segregate from inhibitory SIRPα upon activation of human macrophages

Abstract:

Signal integration between activating Fc receptors and inhibitory signal regulatory protein α (SIRPα) controls macrophage phagocytosis. Here, using dual-color direct stochastic optical reconstruction microscopy, we report that Fcγ receptor I (FcγRI), FcγRII, and SIRPα are not homogeneously distributed at macrophage surfaces but are organized in discrete nanoclusters, with a mean radius of 71 ± 11 nm, 60 ± 6 nm, and 48 ± 3 nm, respectively. Nanoclusters of FcγRI, but not FcγRII, are constituti...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1083/jcb.201608094

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
More from this funder
Name:
Medical Research Council
Funding agency for:
Davis, D
Grant:
110091
More from this funder
Name:
Wellcome Trust
Funding agency for:
Felce, J
Dustin, M
Davis, D
Grant:
107375AIA
100262/Z/12/Z
110091
More from this funder
Name:
Manchester Collaborative Centre for Inflammation Research
Publisher:
Rockefeller University Press
Journal:
Journal of Cell Biology More from this journal
Volume:
216
Issue:
4
Pages:
1123-1141
Publication date:
2017-03-13
Acceptance date:
2017-01-30
DOI:
EISSN:
1540-8140
ISSN:
0021-9525
Language:
English
Keywords:
Pubs id:
pubs:686089
UUID:
uuid:61f05442-bbc4-4e12-a12c-fb8d919f0eb6
Local pid:
pubs:686089
Source identifiers:
686089
Deposit date:
2017-03-17

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