- Abstract:
-
BACKGROUND: Evidence indicates that myocardial NO production can modulate contractility, but the source of NO remains uncertain. Here, we investigated the role of a type 1 NO synthase isoform (NOS1), which has been recently localized to the cardiac sarcoplasmic reticulum, in the regulation of basal and beta-adrenergic myocardial contraction. METHODS AND RESULTS: Contraction was assessed in left ventricular myocytes isolated from mice with NOS1 gene disruption (NOS1(-/-) mice) and their litte...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1161/01.cir.0000019516.31040.2d
-
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- Journal:
- Circulation
- Volume:
- 105
- Issue:
- 25
- Pages:
- 3011-3016
- Publication date:
- 2002-06-05
- DOI:
- EISSN:
-
1524-4539
- ISSN:
-
0009-7322
- URN:
-
uuid:61cb1200-65a6-48fe-a932-835759f82a01
- Source identifiers:
-
104195
- Local pid:
- pubs:104195
- Language:
- English
- Keywords:
- Copyright date:
- 2002
Journal article
Cardiac nitric oxide synthase 1 regulates basal and beta-adrenergic contractility in murine ventricular myocytes.
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