Journal article
NAADP induces Ca2+ oscillations via a two-pool mechanism by priming IP3- and cADPR-sensitive Ca2+ stores.
- Abstract:
-
In sea urchin eggs, Ca2+ mobilization by nicotinic acid adenine dinucleotide phosphate (NAADP) potently self-inactivates but paradoxically induces long-term Ca2+ oscillations. We investigated whether NAADP-induced Ca2+ oscillations arise from the recruitment of other Ca2+ release pathways. NAADP, inositol trisphosphate (IP3) and cyclic ADP-ribose (cADPR) all mobilized Ca2+ from internal stores but only NAADP consistently induced Ca2+ oscillations. NAADP-induced Ca2+ oscillations were partiall...
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- Publication status:
- Published
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- Publisher copy:
- 10.1093/emboj/20.11.2666
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Authors
Bibliographic Details
- Journal:
- The EMBO journal
- Volume:
- 20
- Issue:
- 11
- Pages:
- 2666-2671
- Publication date:
- 2001-06-05
- DOI:
- EISSN:
-
1460-2075
- ISSN:
-
0261-4189
- URN:
-
uuid:61c70526-d1b5-4fa8-9199-6cdb4ef3cb6c
- Source identifiers:
-
106448
- Local pid:
- pubs:106448
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright date:
- 2001
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