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NAADP induces Ca2+ oscillations via a two-pool mechanism by priming IP3- and cADPR-sensitive Ca2+ stores.

Abstract:

In sea urchin eggs, Ca2+ mobilization by nicotinic acid adenine dinucleotide phosphate (NAADP) potently self-inactivates but paradoxically induces long-term Ca2+ oscillations. We investigated whether NAADP-induced Ca2+ oscillations arise from the recruitment of other Ca2+ release pathways. NAADP, inositol trisphosphate (IP3) and cyclic ADP-ribose (cADPR) all mobilized Ca2+ from internal stores but only NAADP consistently induced Ca2+ oscillations. NAADP-induced Ca2+ oscillations were partiall...

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Publication status:
Published

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Publisher copy:
10.1093/emboj/20.11.2666

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology, BHF Centre of Research Excellence
Journal:
The EMBO journal
Volume:
20
Issue:
11
Pages:
2666-2671
Publication date:
2001-06-05
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
URN:
uuid:61c70526-d1b5-4fa8-9199-6cdb4ef3cb6c
Source identifiers:
106448
Local pid:
pubs:106448

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