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Hepatic expression of secondary lymphoid chemokine (CCL21) promotes the development of portal-associated lymphoid tissue in chronic inflammatory liver disease.

Abstract:

The chronic inflammatory liver disease primary sclerosing cholangitis (PSC) is associated with portal inflammation and the development of neolymphoid tissue in the liver. More than 70% of patients with PSC have a history of inflammatory bowel disease and we have previously reported that mucosal addressin cell adhesion molecule-1 is induced on dendritic cells and portal vascular endothelium in PSC. We now show that the lymph node-associated chemokine, CCL21 or secondary lymphoid chemokine, is ...

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Publication status:
Published

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Journal:
American journal of pathology More from this journal
Volume:
160
Issue:
4
Pages:
1445-1455
Publication date:
2002-04-01
DOI:
EISSN:
1525-2191
ISSN:
0002-9440
Language:
English
Keywords:
Pubs id:
pubs:102760
UUID:
uuid:61ada8a4-bd06-4b3c-bb18-54bd367f8d34
Local pid:
pubs:102760
Source identifiers:
102760
Deposit date:
2012-12-19

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