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Journal article

Measles virus transmembrane fusion protein synthesized de novo or presented in immunostimulating complexes is endogenously processed for HLA class I- and class II-restricted cytotoxic T cell recognition.

Abstract:

The routes used by antigen-presenting cells (APC) to convert the transmembrane fusion glycoprotein (F) of measles virus (MV) to HLA class I and class II presentable peptides have been examined, using cloned cytotoxic T lymphocytes in functional assays. Presentation by Epstein-Barr virus-transformed B lymphoblastoid cell lines was achieved using live virus, ultraviolet light-inactivated virus, and purified MV-F delivered either as such or incorporated in immunostimulating complexes (MV-F-ISCOM...

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Publication status:
Published

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Publisher copy:
10.1084/jem.176.1.119

Authors


van Binnendijk, RS More by this author
van Baalen, CA More by this author
Poelen, MC More by this author
de Vries, P More by this author
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Journal:
The Journal of experimental medicine
Volume:
176
Issue:
1
Pages:
119-128
Publication date:
1992-07-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:61783615-378e-48b8-9b6c-23f790543915
Source identifiers:
33216
Local pid:
pubs:33216

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