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Interactions between Shh, Sostdc1 and Wnt signaling and a new feedback loop for spatial patterning of the teeth

Abstract:

Each vertebrate species displays specific tooth patterns in each quadrant of the jaw: the mouse has one incisor and three molars, which develop at precise locations and at different times. The reason why multiple teeth form in the jaw of vertebrates and the way in which they develop separately from each other have been extensively studied, but the genetic mechanism governing the spatial patterning of teeth still remains to be elucidated. Sonic hedgehog (Shh) is one of the key signaling molecu...

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Publisher:
Development
Publication date:
2011-01-01
UUID:
uuid:61706873-18d2-42b0-a2fa-588bc833b87a
Local pid:
oai:eprints.maths.ox.ac.uk:1059
Deposit date:
2011-05-20

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