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Journal article

Stalk cell phenotype depends on integration of Notch and Smad1/5 signaling cascades.

Abstract:

Gradients of vascular endothelial growth factor (VEGF) induce single endothelial cells to become leading tip cells of emerging angiogenic sprouts. Tip cells then suppress tip-cell features in adjacent stalk cells via Dll4/Notch-mediated lateral inhibition. We report here that Smad1/Smad5-mediated BMP signaling synergizes with Notch signaling during selection of tip and stalk cells. Endothelium-specific inactivation of Smad1/Smad5 in mouse embryos results in impaired Dll4/Notch signaling and i...

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Journal:
Developmental cell
Volume:
22
Issue:
3
Pages:
501-514
Publication date:
2012-03-05
DOI:
EISSN:
1878-1551
ISSN:
1534-5807
URN:
uuid:616c31e8-991d-49e8-8ca9-fa56d16f24b5
Source identifiers:
321374
Local pid:
pubs:321374

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