- Abstract:
-
Gradients of vascular endothelial growth factor (VEGF) induce single endothelial cells to become leading tip cells of emerging angiogenic sprouts. Tip cells then suppress tip-cell features in adjacent stalk cells via Dll4/Notch-mediated lateral inhibition. We report here that Smad1/Smad5-mediated BMP signaling synergizes with Notch signaling during selection of tip and stalk cells. Endothelium-specific inactivation of Smad1/Smad5 in mouse embryos results in impaired Dll4/Notch signaling and i...
Expand abstract - Publisher copy:
- 10.1016/j.devcel.2012.01.007
-
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- Journal:
- Developmental cell
- Volume:
- 22
- Issue:
- 3
- Pages:
- 501-514
- Publication date:
- 2012-03-05
- DOI:
- EISSN:
-
1878-1551
- ISSN:
-
1534-5807
- URN:
-
uuid:616c31e8-991d-49e8-8ca9-fa56d16f24b5
- Source identifiers:
-
321374
- Local pid:
- pubs:321374
- Language:
- English
- Keywords:
- Copyright date:
- 2012
Journal article
Stalk cell phenotype depends on integration of Notch and Smad1/5 signaling cascades.
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