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Intracellular complement activation—An alarm raising mechanism?

Abstract:

It has become increasingly apparent that the complement system, being an ancient defense mechanism, is not operative only in the extracellular milieu but also intracellularly. In addition to the known synthetic machinery in the liver and by macrophages, many other cell types, including lymphocytes, adipocytes and epithelial cells produce selected complement components. Activation of e.g. C3 and C5 inside cells may have multiple effects ranging from direct antimicrobial defense to cell differe...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/j.smim.2018.03.003

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Finnish Cultural Foundation More from this funder
The Academy of Finland More from this funder
The Helsinki University Hospital Grant (EVO) More from this funder
Sigrid Jusélius Foundation More from this funder
Signe and Ane Gyllenberg Foundation More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Seminars in Immunology Journal website
Volume:
38
Pages:
54-62
Publication date:
2018-04-07
Acceptance date:
2018-03-26
DOI:
EISSN:
1096-3618
ISSN:
1044-5323
Pubs id:
pubs:867289
URN:
uri:61673cc3-bc41-4b65-b66b-7fb5c8abf7b3
UUID:
uuid:61673cc3-bc41-4b65-b66b-7fb5c8abf7b3
Local pid:
pubs:867289

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