- Abstract:
-
It has become increasingly apparent that the complement system, being an ancient defense mechanism, is not operative only in the extracellular milieu but also intracellularly. In addition to the known synthetic machinery in the liver and by macrophages, many other cell types, including lymphocytes, adipocytes and epithelial cells produce selected complement components. Activation of e.g. C3 and C5 inside cells may have multiple effects ranging from direct antimicrobial defense to cell differe...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted Manuscript
- Files:
-
-
(pdf, 192.7kb)
-
- Publisher copy:
- 10.1016/j.smim.2018.03.003
-
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- Publisher:
- Elsevier Publisher's website
- Journal:
- Seminars in Immunology Journal website
- Volume:
- 38
- Pages:
- 54-62
- Publication date:
- 2018-04-07
- Acceptance date:
- 2018-03-26
- DOI:
- EISSN:
-
1096-3618
- ISSN:
-
1044-5323
- Pubs id:
-
pubs:867289
- URN:
-
uri:61673cc3-bc41-4b65-b66b-7fb5c8abf7b3
- UUID:
-
uuid:61673cc3-bc41-4b65-b66b-7fb5c8abf7b3
- Local pid:
- pubs:867289
- Language:
- English
- Keywords:
- Copyright holder:
- Elsevier Ltd.
- Copyright date:
- 2018
- Notes:
- © 2018 Published by Elsevier Ltd. This is the accepted manuscript version of the article. The final version is available online from Elsevier at: https://doi.org/10.1016/j.smim.2018.03.003
Journal article
Intracellular complement activation—An alarm raising mechanism?
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Finnish Cultural Foundation
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The Academy of Finland
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The Helsinki University Hospital Grant (EVO)
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Sigrid Jusélius Foundation
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Signe and Ane Gyllenberg Foundation
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