Journal article : Review
Effect of CPAP on cardiovascular events in minimally symptomatic OSA: long-term follow-up of the MOSAIC randomised controlled trial
- Abstract:
- The effect of continuous positive airway pressure (CPAP) on cardiovascular events is uncertain in minimally symptomatic obstructive sleep apnoea. Previous 2-year follow-up data from the Multicentre Obstructive Sleep Apnoea Intervention Cardiovascular (MOSAIC) trial showed a marginal reduction in cardiovascular events with CPAP therapy. We now present long-term MOSAIC study follow-up data. Median (first quartile, third quartile) follow-up was 5.0 (2.2, 5.0) and 3.7 (1.5, 5.0) years for CPAP and standard care, respectively. Compared to standard care, CPAP had no statistically significant effect on the risk of cardiovascular events (HR=0.83, p=0.54, 95% CI 0.46-1.51).
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 275.2KB, Terms of use)
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- Publisher copy:
- 10.1136/bmjresp-2020-000742
Authors
- Publisher:
- BMJ
- Journal:
- BMJ Open Respiratory Research More from this journal
- Volume:
- 7
- Issue:
- 1
- Article number:
- e000742
- Place of publication:
- England
- Publication date:
- 2020-09-14
- Acceptance date:
- 2020-08-16
- DOI:
- EISSN:
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2052-4439
- ISSN:
-
2052-4439
- Pmid:
-
32928788
- Language:
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English
- Keywords:
- Subtype:
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Review
- Pubs id:
-
1133543
- Local pid:
-
pubs:1133543
- Deposit date:
-
2020-10-05
Terms of use
- Copyright holder:
- Tang et al.
- Copyright date:
- 2020
- Rights statement:
- © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial.
- Licence:
- CC Attribution (CC BY)
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