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Voltage sensitivity of the osteoclast calcium receptor.

Abstract:

We demonstrated previously that osteoclasts possess a divalent cation-sensitive "receptor", the Ca2+ receptor. Activation of the Ca2+ receptor by the surrogate cation Ni2+ was shown to elicit an increase in cytosolic [Ca2+] to a peak value followed by an exponential decline. In the present study we examined the influence of surface membrane voltage on the kinetics of Ca2+ receptor inactivation. The K+ ionophore, valinomycin was applied to intercept the declining phase of the cytosolic [Ca2+] ...

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Publisher copy:
10.1006/bbrc.1993.1530

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Moonga, BS More by this author
Shankar, VS More by this author
Journal:
Biochemical and biophysical research communications
Volume:
192
Issue:
3
Pages:
1100-1105
Publication date:
1993-05-05
DOI:
EISSN:
1090-2104
ISSN:
0006-291X
URN:
uuid:615334ac-c1d0-4622-89bb-a7c3821a0c4a
Source identifiers:
475721
Local pid:
pubs:475721

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