Arginine methylation regulates the p53 response.

Journal article

Activation of the p53 tumour suppressor protein in response to DNA damage leads to apoptosis or cell-cycle arrest. Enzymatic modifications are widely believed to affect and regulate p53 activity. We describe here a level of post-translational control that has an important functional consequence on the p53 response. We show that the protein arginine methyltransferase (PRMT) 5, as a co-factor in a DNA damage responsive co-activator complex that interacts with p53, is responsible for methylating...

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Authors: Jansson, M; Durant, S; Cho, E; Sheahan, S; Edelmann, M

• Publication status: Published
• Journal: Nature cell biology
• Volume: 10
• Issue: 12
• Pages: 1431-1439
• Publication date: 2008-12-01
• DOI: 10.1038/ncb1802
• EISSN: 1476-4679
• ISSN: 1465-7392
• Language: English
• Keywords: Arginine; Amino Acid Sequence; Molecular Sequence Data; Protein-Arginine N-Methyltransferases; Protein Transport; Protein Methyltransferases; Protein Binding; Hela Cells; Tumor Suppressor Protein p53; Methylation; Protein Structure, Quaternary; Apoptosis; Mutant Proteins; Humans; Carrier Proteins