Induction of inflammatory bowel disease in immunodeficient mice by depletion of regulatory T cells.

Journal article

The severe combined immunodeficiency (SCID) model of colitis shares many features of idiopathic inflammatory bowel disease (IBD) in humans. The SCID model is highly reproducible and easily manipulated, and as such provides a useful tool for studying mucosal immune regulation as it relates to the pathogenesis and treatment of IBD in humans. This unit describes a cell transfer system in which SCID mice are reconstituted with CD4(+) CD45RB(high) cells to induce IBD. The CD4(+) cells are isolated...

Expand abstract

Authors: Read, S; Powrie, F

• Journal: Current protocols in immunology / edited by John E. Coligan ... [et al.]
• Volume: Chapter 15
• Pages: Unit-15.13
• Publication date: 2001-05-01
• DOI: 10.1002/0471142735.im1513s30
• EISSN: 1934-368X
• ISSN: 1934-3671
• Language: English
• Keywords: T-Lymphocytes, Regulatory; Inflammatory Bowel Diseases; CD4-Positive T-Lymphocytes; Animals; Mice; Mice, SCID; Mice, Inbred BALB C; Adoptive Transfer; Lymphocyte Depletion; Female; Disease Models, Animal