Journal article
An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2
- Abstract:
-
Background Mutations in LRRK2 are the most common cause of autosomal dominant Parkinson's disease, and the relevance of LRRK2 to the sporadic form of the disease is becoming ever more apparent. It is therefore essential that studies are conducted to improve our understanding of the cellular role of this protein. Here we use multiple models and techniques to identify the pathways through which LRRK2 mutations may lead to the development of Parkinson's disease.
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Neurobiology of Disease Journal website
- Volume:
- 127
- Pages:
- 512-526
- Publication date:
- 2019-04-05
- Acceptance date:
- 2019-04-03
- DOI:
- ISSN:
-
0969-9961
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:987997
- UUID:
-
uuid:61334663-ec44-4d89-bbcc-ae51f2a2f004
- Local pid:
- pubs:987997
- Deposit date:
- 2019-04-15
Terms of use
- Copyright holder:
- Elsevier Inc
- Copyright date:
- 2019
- Notes:
- © 2019 Published by Elsevier Inc. Under a Creative Commons license
- Licence:
- CC Attribution (CC BY)
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