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Pre-eclampsia, the placenta and the maternal systemic inflammatory response--a review.

Abstract:

The central role of the placenta in the pathogenesis of pre-eclampsia is undisputed. The evidence that maternal syndrome of pre-eclampsia is caused by a maternal systemic inflammatory response (MSIR) is reviewed. The polymorphic nature of the inflammatory network explains the diversity of the varied signs of this condition. A key observation is that an MSIR is also a feature of normal third trimester pregnancy, but less severe than in pre-eclampsia. Hence pre-eclampsia is simply the extreme e...

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Publication status:
Published

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Publisher copy:
10.1053/plac.2002.0930

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Obstetrics and Gynaecology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Obstetrics and Gynaecology
Journal:
Placenta
Volume:
24 Suppl A
Issue:
SUPPL. A
Pages:
S21-S27
Publication date:
2003-04-05
DOI:
EISSN:
1532-3102
ISSN:
0143-4004
URN:
uuid:612489cb-98ae-4869-b3d6-cf3b0fa0ddd5
Source identifiers:
248189
Local pid:
pubs:248189

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