Conference item
The interplay between JNK pathway activation, proteoglycan turnover and endocytosis in chondrocytes
- Abstract:
- The JNK pathway (c-jun N-terminal kinase) is activated by a variety of inflammatory and physical stressful stimuli. Recently, we identified a new and an important role for the JNK pathway in the turnover of the cartilage proteoglycan aggrecan. Loss of JNK2 isoform in human chondrocytes and murine cartilage abolished IL1- induced aggrecan degradation and aggrecanase activity. Furthermore, JNK2-null mice were protected from surgically-induced osteoarthritis. Here we show that the JNK2-dependent effect on the aggrecan degradation is linked to an LRP1-dependent endocytic mechanism.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Access Document
- Files:
-
-
(Preview, Accepted manuscript, pdf, 28.9KB, Terms of use)
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- Publisher copy:
- 10.1111/iep.12235
Authors
- Publisher:
- Wiley
- Host title:
- International Journal of Experimental Pathology
- Journal:
- International Journal of Experimental Pathology More from this journal
- Volume:
- 98
- Issue:
- 3
- Pages:
- A17-A18
- Publication date:
- 2017-08-28
- DOI:
- EISSN:
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1365-2613
- ISSN:
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0959-9673
- Pubs id:
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pubs:728949
- UUID:
-
uuid:61122c25-4b7b-49be-8eab-fe97fdc481fd
- Local pid:
-
pubs:728949
- Source identifiers:
-
728949
- Deposit date:
-
2017-11-21
Terms of use
- Copyright holder:
- Ismail et al
- Copyright date:
- 2017
- Notes:
- This is the author accepted manuscript following peer review version of the article. The final version is available online from Wiley at: 10.1111/iep.12235
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