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Safety profile of the viral vectors of attenuated fowlpox strain FP9 and modified vaccinia virus Ankara recombinant for either of 2 preerythrocytic malaria antigens, ME-TRAP or the circumsporozoite protein, in children and adults in Kenya

Abstract:

Background. We are developing a heterologous prime-boost vaccine strategy against malaria. This approach uses sequential immunization with different vectors to deliver a common preerythrocytic malaria antigen. Preliminary evidence of efficacy and safety has been previously documented in studies from an area where malaria is nonendemic. Additional safety data from an area where malaria is endemic are now required before larger-scale studies are undertaken to determine the efficacy of this vacc...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
"Kenya Medical Research Institute, Centre for Geographical Medical Research (Coast), Kilifi, Kenya", "University of Oxford"
Department:
Medical Sciences Division - Clinical Vaccinology and Tropical Medicine,Centre for (CCVTM)
Role:
Author
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Institution:
"Kenya Medical Research Institute, Centre for Geographical Medical Research (Coast), Kilifi, Kenya"
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
"Kenya Medical Research Institute, Centre for Geographical Medical Research (Coast), Kilifi, Kenya"
Role:
Author
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Institution:
"Kenya Medical Research Institute, Centre for Geographical Medical Research (Coast), Kilifi, Kenya"
Role:
Author
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Contributors

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Funding agency for:
Hill, A
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Funding agency for:
Marsh, K
Grant:
061702
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Funding agency for:
Bejon, P
Grant:
073597
Publisher:
University of Chicago Press Publisher's website
Journal:
Clinical Infectious Diseases Journal website
Volume:
42
Issue:
8
Pages:
1102-10
Publication date:
2006-04-01
ISSN:
1058-4838
Language:
English
Keywords:
Subjects:
UUID:
uuid:610c089b-431b-456c-821b-94df8e183824
Local pid:
ora:995
Deposit date:
2008-03-14

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