Local computational methods to improve the interpretability and analysis of cryo-EM maps

Journal article

The sarcomere is the basic unit of striated muscles and consists of interdigitating thick and thin filaments. The two types of filaments slide on each other resulting in the shortening of sarcomere itself thereby generating work. The thin filament comprises filamentous actin (F-actin), troponin (Tn), and tropomyosin (Tm). The thick filament is the force bearing part of the sarcomere and it comprises myosin, titin, and myosin-binding protein C (MyBP-C). The vast majority of ...

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Authors: Kaur, S; Gomez-Blanco, J; Khalifa, AAZ; Adinarayanan, S; Sanchez-Garcia, R

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Nature Research
• Journal: Nature Communications
• Volume: 12
• Issue: 1
• Pages: 1240-1240
• Article number: 1240
• Publication date: 2021-02-23
• DOI: 10.1038/s41467-021-21509-5
• EISSN: 2041-1723
• ISSN: 2041-1723
• Language: English
• Keywords: Physics; Cryo-electron microscopy; Resolution (logic); Data mining; Computer science; Interpretability; Transformation (genetics); Sharpening; Biology; Nuclear magnetic resonance; Artificial intelligence