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The biogenesis and characterization of mammalian microRNAs of mirtron origin.

Abstract:

Mirtrons, short hairpin pre-microRNA (miRNA) mimics directly produced by intronic splicing, have recently been identified and experimentally confirmed in invertebrates. While there is evidence to suggest several mammalian miRNAs have mirtron origins, this has yet to be experimentally demonstrated. Here, we characterize the biogenesis of mammalian mirtrons by ectopic expression of splicing-dependent mirtron precursors. The putative mirtrons hsa-miR-877, hsa-miR-1226 and mmu-miR-1224 were desig...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/nar/gkr722

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
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Funding agency for:
Wood, MJ
Medical Research Council More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic acids research Journal website
Volume:
40
Issue:
1
Pages:
438-448
Publication date:
2012-01-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:60f4e265-82a7-48d6-b8c0-d3e203db5116
Source identifiers:
175229
Local pid:
pubs:175229

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