Analytical evaluation of thirty-two severe acute respiratory syndrome 2 lateral flow antigen tests demonstrates sensitivity remains with the SARS-CoV-2 Gamma lineage

Journal article

Background: The emergence of variants of concern (VOCs) requires an ongoing assessment of the performance of antigen lateral flow tests (Ag-RDTs). The limit of detection (LOD) of 32 Ag-RDTs was evaluated using the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Gamma variant. Methods: Ag-RDTs were performed according to the manufacturer’s instructions with a clinical isolate of the Gamma variant. Results: Twenty-eight of the 32 Ag-RDTs exceeded the World Health Organization criteria. Conclusions: This comprehensive analytical evaluation of Ag-RDTs demonstrated that the test performance was maintained with Gamma VOC

Authors: Kontogianni, K; Bengey, D; Wooding, D; Buist, K; Greenland-Bews, C

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: FapUNIFESP (SciELO)
• Journal: Revista da Sociedade Brasileira de Medicina Tropical
• Volume: 55
• Pages: e0016-e0016
• Publication date: 2022-06-06
• DOI: 10.1590/0037-8682-0016-2022
• EISSN: 1678-9849
• ISSN: 0037-8682
• Language: English
• Keywords: Medicine; Respiratory system; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Internal medicine; Virology; Disease; Coronavirus disease 2019 (COVID-19); Antigen; 2019-20 coronavirus outbreak; Immunology