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Keeping IGF-II under control: lessons from the IGF-II-IGF2R crystal structure.

Abstract:

Insulin-like growth factor-II (IGF-II) is a key regulator of cell growth, survival, migration and differentiation. Its pivotal role in these processes requires tight regulation of both expression and activity. The type 1 IGF receptor tyrosine kinase (IGF-1R) mediates IGF-II actions, and a family of six high affinity IGF binding proteins (IGFBPs) regulates IGF-II circulating half-life and its availability to bind IGF-1R. In addition, the type 2 IGF receptor (IGF2R; also called the cation-indep...

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Publication status:
Published

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Publisher copy:
10.1016/j.tibs.2009.07.003

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Forbes, BE More by this author
Journal:
Trends in biochemical sciences
Volume:
34
Issue:
12
Pages:
612-619
Publication date:
2009-12-05
DOI:
ISSN:
0968-0004
URN:
uuid:60da56ae-f6a1-47a3-a832-24b22e12a3ee
Source identifiers:
10551
Local pid:
pubs:10551

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