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Phylogenetic analysis of murine leukemia virus sequences from longitudinally sampled chronic fatigue syndrome patients suggests PCR contamination rather than viral evolution.

Abstract:

Xenotropic murine leukemia virus (MLV)-related virus (XMRV) has been amplified from human prostate cancer and chronic fatigue syndrome (CFS) patient samples. Other studies failed to replicate these findings and suggested PCR contamination with a prostate cancer cell line, 22Rv1, as a likely source. MLV-like sequences have also been detected in CFS patients in longitudinal samples 15 years apart. Here, we tested whether sequence data from these samples are consistent with viral evolution. Our ...

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Publication status:
Published

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Publisher copy:
10.1128/jvi.00827-11

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Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Role:
Author
Journal:
Journal of virology
Volume:
85
Issue:
20
Pages:
10909-10913
Publication date:
2011-10-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:60d9697b-245d-4111-9f97-5970ccaf5ff7
Source identifiers:
209363
Local pid:
pubs:209363

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