- Abstract:
-
Ca(2+) signaling regulates cell function. This is subject to modulation by H(+) ions that are universal end-products of metabolism. Due to slow diffusion and common buffers, changes in cytoplasmic [Ca(2+)] ([Ca(2+)]i) or [H(+)] ([H(+)]i) can become compartmentalized, leading potentially to complex spatial Ca(2+)/H(+) coupling. This was studied by fluorescence imaging of cardiac myocytes. An increase in [H(+)]i, produced by superfusion of acetate (salt of membrane-permeant weak acid), evoked a...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1073/pnas.1222433110
-
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- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Volume:
- 110
- Issue:
- 22
- Pages:
- E2064-E2073
- Publication date:
- 2013-05-05
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- URN:
-
uuid:60d890b8-fc4e-443c-8911-379b16ffe7a5
- Source identifiers:
-
400679
- Local pid:
- pubs:400679
- Language:
- English
- Keywords:
- Copyright date:
- 2013
Journal article
Coupled Ca2+/H+ transport by cytoplasmic buffers regulates local Ca2+ and H+ ion signaling.
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