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Coupled Ca2+/H+ transport by cytoplasmic buffers regulates local Ca2+ and H+ ion signaling.

Abstract:

Ca(2+) signaling regulates cell function. This is subject to modulation by H(+) ions that are universal end-products of metabolism. Due to slow diffusion and common buffers, changes in cytoplasmic [Ca(2+)] ([Ca(2+)]i) or [H(+)] ([H(+)]i) can become compartmentalized, leading potentially to complex spatial Ca(2+)/H(+) coupling. This was studied by fluorescence imaging of cardiac myocytes. An increase in [H(+)]i, produced by superfusion of acetate (salt of membrane-permeant weak acid), evoked a...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1222433110

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
Role:
Author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
110
Issue:
22
Pages:
E2064-E2073
Publication date:
2013-05-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:60d890b8-fc4e-443c-8911-379b16ffe7a5
Source identifiers:
400679
Local pid:
pubs:400679

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