- Abstract:
-
1. Plasma concentrations of alpha 1-acid glycoprotein (AAG) and plasma protein binding of quinine were measured in 97 Thai adults with acute falciparum malaria. There was a linear relationship between log AAG and percentage quinine binding (r = 0.71, P less than 0.001) in vivo, which was similar to that observed in vitro; the slopes and intercepts of the regression lines at AAG concentrations of 1 g l-1 were -8.94 and -8.41, and 7.2% and 10.9%, respectively. 2. Hill plots from these data sugg...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1111/j.1365-2125.1991.tb03904.x
-
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- Journal:
- British journal of clinical pharmacology
- Volume:
- 32
- Issue:
- 3
- Pages:
- 311-315
- Publication date:
- 1991-09-05
- DOI:
- EISSN:
-
1365-2125
- ISSN:
-
0306-5251
- URN:
-
uuid:60c85c2c-8e20-425f-bf0e-105a220f773d
- Source identifiers:
-
95497
- Local pid:
- pubs:95497
- Language:
- English
- Keywords:
- Copyright date:
- 1991
Journal article
Alpha 1-acid glycoprotein (orosomucoid) and plasma protein binding of quinine in falciparum malaria.
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