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Alpha 1-acid glycoprotein (orosomucoid) and plasma protein binding of quinine in falciparum malaria.

Abstract:

1. Plasma concentrations of alpha 1-acid glycoprotein (AAG) and plasma protein binding of quinine were measured in 97 Thai adults with acute falciparum malaria. There was a linear relationship between log AAG and percentage quinine binding (r = 0.71, P less than 0.001) in vivo, which was similar to that observed in vitro; the slopes and intercepts of the regression lines at AAG concentrations of 1 g l-1 were -8.94 and -8.41, and 7.2% and 10.9%, respectively. 2. Hill plots from these data sugg...

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Publication status:
Published

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Authors


Silamut, K More by this author
Molunto, P More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Journal:
British journal of clinical pharmacology
Volume:
32
Issue:
3
Pages:
311-315
Publication date:
1991-09-05
DOI:
EISSN:
1365-2125
ISSN:
0306-5251
URN:
uuid:60c85c2c-8e20-425f-bf0e-105a220f773d
Source identifiers:
95497
Local pid:
pubs:95497

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