Dexamethasone Attenuates VEGF Expression and Inflammation but Not Barrier Dysfunction in a Murine Model of Ventilator–Induced Lung Injury

Journal article

Dexamethasone treatment completely abolishes ventilator-induced VEGF expression and inflammation. However, dexamethasone does not protect against alveolar-capillary barrier dysfunction in an established murine model of VILI.

Authors: Hegeman, MA; Hennus, MP; Cobelens, PM; Kavelaars, A; Jansen, NJG

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Public Library of Science
• Journal: PLoS ONE
• Volume: 8
• Issue: 2
• Pages: e57374-e57374
• Publication date: 2013-02-25
• DOI: 10.1371/journal.pone.0057374
• EISSN: 1932-6203
• ISSN: 1932-6203
• Language: English
• Keywords: Internal medicine; VEGF receptors; Vascular permeability; Mechanical ventilation; Vascular endothelial growth factor; Immunology; Ventilation (architecture); Bronchoalveolar lavage; Lung; Anesthesia; Medicine; Dexamethasone; Inflammation; Pulmonary edema