Journal article

Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: A meta-analysis of individual patient data from randomised trials

Abstract:: Background Alteplase is effective for treatment of acute ischaemic stroke but debate continues about its use after longer times since stroke onset, in older patients, and among patients who have had the least or most severe strokes. We assessed the role of these factors in affecting good stroke outcome in patients given alteplase. Methods We did a pre-specified meta-analysis of individual patient data from 6756 patients in nine randomised trials comparing alteplase with placebo or open contro...
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APA Style

Emberson, J., Lees, K., Lyden, P., Blackwell, L., Albers, G., Bluhmki, E., Brott, T., Cohen, G., Davis, S., Donnan, G., Grotta, J., Howard, G., Kaste, M., Koga, M., Von Kummer, R., Lansberg, M., Lindley, R., Murray, G., Olivot, J., … Wardlaw, J. (2014). Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: A meta-analysis of individual patient data from randomised trials. Lancet, 384(9958), 1929–1935.

MLA Style

Emberson, J, et al. “Effect of Treatment Delay, Age, and Stroke Severity on the Effects of Intravenous Thrombolysis with Alteplase for Acute Ischaemic Stroke: A Meta-Analysis of Individual Patient Data from Randomised Trials.” Lancet, vol. 384, no. 9958, 2014, pp. 1929–35.

Chicago Style

Emberson, J, K Lees, P Lyden, et al. 2014. “Effect of Treatment Delay, Age, and Stroke Severity on the Effects of Intravenous Thrombolysis with Alteplase for Acute Ischaemic Stroke: A Meta-Analysis of Individual Patient Data from Randomised Trials.” Lancet 384 (9958): 1929–35.
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Publisher copy:: 10.1016/S0140-6736(14)60584-5

Authors

+ Emberson, J More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Nuffield Department of Population Health
Sub department:: Clinical Trial Service Unit
Role:: Author

+ Lees, K More by this author

Role:: Author

+ Lyden, P More by this author

Role:: Author

+ Blackwell, L More by this author

Role:: Author

+ Albers, G More by this author

Role:: Author

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Publisher:: Lancet
Journal:: Lancet More from this journal
Volume:: 384
Issue:: 9958
Pages:: 1929-1935
Publication date:: 2014-11-29
DOI:: 10.1016/S0140-6736(14)60584-5
EISSN:: 1474-547X
ISSN:: 0140-6736

Language:: English
Pubs id:: pubs:502508
UUID:: uuid:60994f99-f077-47ba-950d-4188ff06b947
Local pid:: pubs:502508
Source identifiers:: 502508
Deposit date:: 2015-01-15
ARK identifier:: ark:/29072/ora_60994f99f07747ba950d4188ff06b947

Terms of use

Copyright date:: 2014

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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