Journal article icon

Journal article

Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: A meta-analysis of individual patient data from randomised trials

Abstract:

Background Alteplase is effective for treatment of acute ischaemic stroke but debate continues about its use after longer times since stroke onset, in older patients, and among patients who have had the least or most severe strokes. We assessed the role of these factors in affecting good stroke outcome in patients given alteplase. Methods We did a pre-specified meta-analysis of individual patient data from 6756 patients in nine randomised trials comparing alteplase with placebo or open contro...

Expand abstract

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Trial Service Unit, BHF Centre of Research Excellence
Blackwell, L More by this author
Expand authors...
Publisher:
Lancet Publishing Group
Journal:
The Lancet
Volume:
384
Issue:
9958
Pages:
1929-1935
Publication date:
2014-11-29
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:60994f99-f077-47ba-950d-4188ff06b947
Source identifiers:
502508
Local pid:
pubs:502508
Language:
English

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP