Journal article
Amino acid sensing by mTORC1: intracellular transporters mark the spot
- Abstract:
- Cell metabolism and growth are matched to nutrient availability via the amino-acid-regulated mechanistic target of rapamycin complex 1 (mTORC1). Transporters have emerged as important amino acid sensors controlling mTOR recruitment and activation at the surface of multiple intracellular compartments. Classically, this has involved late endosomes and lysosomes, but now, in a recent twist, also the Golgi apparatus. Here we propose a model in which specific amino acids in assorted compartments activate different mTORC1 complexes, which may have distinct drug sensitivities and functions. We will discuss the implications of this for mTORC1 function in health and disease.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, pdf, 2.3MB, Terms of use)
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- Publisher copy:
- 10.1016/j.cmet.2016.03.013
Authors
- Publisher:
- Elsevier
- Journal:
- Cell Metabolism More from this journal
- Volume:
- 23
- Issue:
- 4
- Pages:
- 580-589
- Publication date:
- 2016-04-12
- Acceptance date:
- 2016-03-26
- DOI:
- ISSN:
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1932-7420
- Keywords:
- Pubs id:
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pubs:624841
- UUID:
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uuid:6091e4af-a2c6-4d00-930e-150205455c23
- Local pid:
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pubs:624841
- Source identifiers:
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624841
- Deposit date:
-
2016-05-29
Terms of use
- Copyright holder:
- Deborah Goberdhan et al
- Copyright date:
- 2016
- Notes:
- This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
- Licence:
- CC Attribution (CC BY)
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