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Efficient enantioselective synthesis of tetramic acids and lactams from threonine

Abstract:
Regioselective Dieckmann and aldol cyclisations using an N-acyloxazolidine derived from threonine give substituted tetramic acids and pyroglutamates in high yield and enantioselectivity. These are easily deprotected under mild conditions to give products, some of which exhibit antibacterial activity. © 2007 Elsevier Ltd. All rights reserved.
Publication status:
Published

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Publisher copy:
10.1016/j.tetlet.2007.08.052

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author


Journal:
TETRAHEDRON LETTERS More from this journal
Volume:
48
Issue:
41
Pages:
7259-7262
Publication date:
2007-10-08
DOI:
ISSN:
0040-4039


Language:
English
Pubs id:
pubs:40541
UUID:
uuid:607b3406-4258-440e-b313-60da9dc4e620
Local pid:
pubs:40541
Source identifiers:
40541
Deposit date:
2012-12-19

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