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IRF5 is required for late-phase TNF secretion by human dendritic cells.

Abstract:

Spatially and temporally controlled expression of inflammatory mediators is critical for an appropriate immune response. In this study, we define the role for interferon regulatory factor 5 (IRF5) in secretion of tumor necrosis factor (TNF) by human dendritic cells (DCs). We demonstrate that DCs but not macrophages have high levels of IRF5 protein, and that IRF5 is responsible for the late-phase expression of TNF, which is absent in macrophages. Sustained TNF secretion is essential for robust...

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Publication status:
Published

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Journal:
Blood
Volume:
115
Issue:
22
Pages:
4421-4430
Publication date:
2010-06-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:60693d97-a440-4e40-866a-f3ac1947f2c1
Source identifiers:
227145
Local pid:
pubs:227145

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