- Abstract:
-
Spatially and temporally controlled expression of inflammatory mediators is critical for an appropriate immune response. In this study, we define the role for interferon regulatory factor 5 (IRF5) in secretion of tumor necrosis factor (TNF) by human dendritic cells (DCs). We demonstrate that DCs but not macrophages have high levels of IRF5 protein, and that IRF5 is responsible for the late-phase expression of TNF, which is absent in macrophages. Sustained TNF secretion is essential for robust...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1182/blood-2010-01-263020
-
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- Journal:
- Blood
- Volume:
- 115
- Issue:
- 22
- Pages:
- 4421-4430
- Publication date:
- 2010-06-05
- DOI:
- EISSN:
-
1528-0020
- ISSN:
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0006-4971
- URN:
-
uuid:60693d97-a440-4e40-866a-f3ac1947f2c1
- Source identifiers:
-
227145
- Local pid:
- pubs:227145
- Language:
- English
- Keywords:
- Copyright date:
- 2010
Journal article
IRF5 is required for late-phase TNF secretion by human dendritic cells.
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