Journal article
Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)
- Abstract:
- Light-activable spatiotemporal control of PROTAC-induced protein degradation was achieved with novel arylazopyrazole photoswitchable PROTACs (AP-PROTACs). The use of a promiscuous kinase inhibitor in the design enables this unique photoswitchable PROTAC to selectively degrade four protein kinases together with on/off optical control using different wavelengths of light
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.6MB, Terms of use)
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- Publisher copy:
- 10.1039/d2cc03092f
- Publication website:
- http://spiral.imperial.ac.uk/bitstream/10044/1/99433/7/d2cc03092f.pdf
Authors
+ Cancer Research UK
More from this funder
- Funder identifier:
- 10.13039/501100000289
- Grant:
- C24523/A25192
+ Marie Sklodowska-Curie Actions
More from this funder
- Funder identifier:
- 10.13039/100018694
- Grant:
- H2020
+ National Science Foundation
More from this funder
- Funder identifier:
- 10.13039/100000001
- Grant:
- DMS 2054251
+ Engineering and Physical Sciences Research Council
More from this funder
- Funder identifier:
- 10.13039/501100000266
- Grant:
- EP/R00188X/1
+ Leverhulme Trust
More from this funder
- Funder identifier:
- 10.13039/501100000275
- Grant:
- RPG-2018-051
- Publisher:
- Royal Society of Chemistry
- Journal:
- Chemical Communications More from this journal
- Volume:
- 58
- Issue:
- 78
- Pages:
- 10933-10936
- Publication date:
- 2022-09-29
- DOI:
- EISSN:
-
1364-548X
- ISSN:
-
1359-7345
- Language:
-
English
- Keywords:
- Pubs id:
-
1800408
- Local pid:
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pubs:1800408
- Source identifiers:
-
W4294000265
- Deposit date:
-
2026-06-09
- ARK identifier:
This ORA record was generated from metadata provided by an external service. It has not been edited by the ORA Team.
Terms of use
- Copyright date:
- 2022
- Licence:
- CC Attribution (CC BY)
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