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Journal article

Genetic variation in 5-hydroxytryptamine transporter expression causes adaptive changes in 5-HT₄ receptor levels.

Abstract:

Genetic variation in 5-HT transporter (5-HTT) expression is a key risk factor for psychiatric disorder and has been linked to changes in the expression of certain 5-HT receptor subtypes. This study investigated the effect of variation in 5-HTT expression on 5-HT₄ receptor levels in both 5-HTT knockout (KO) and overexpressing (OE) mice using autoradiography with the selective 5-HT₄ receptor radioligand, [³H]SB207145. Compared to wild-type (5-HTT⁺/⁺) controls, homozygous 5-HTT KO mice (5-HTT⁻/⁻...

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Publication status:
Published

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Publisher copy:
10.1017/s1461145711001258

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
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Journal:
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP)
Volume:
15
Issue:
8
Pages:
1099-1107
Publication date:
2012-09-05
DOI:
EISSN:
1469-5111
ISSN:
1461-1457
URN:
uuid:602ae6a0-127a-4ba5-9ada-0e0c58084d1b
Source identifiers:
185347
Local pid:
pubs:185347

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