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Journal article

A single nucleotide polymorphism in the MDM2 gene: from a molecular and cellular explanation to clinical effect.

Abstract:

In a recent article, a candidate pathway approach was taken to try to identify single nucleotide polymorphisms (SNP) that make up the genetic variation, which underlies the phenotypic variation seen between individuals in their susceptibility to cancer and the progression of their disease. The p53 stress response pathway was chosen given its well-documented importance in tumor suppression. A SNP was found which associates with the attenuation of the p53 pathway and the acceleration of tumor f...

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Publication status:
Published

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Journal:
Cancer research
Volume:
65
Issue:
13
Pages:
5481-5484
Publication date:
2005-07-05
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:602a8baa-c9a2-4a98-a67e-b76faf74b206
Source identifiers:
69612
Local pid:
pubs:69612

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