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Placental vesicles carry active endothelial nitric oxide synthase and their activity is reduced in preeclampsia..

Abstract:

Preeclampsia, a multisystem hypertensive disorder of pregnancy, is associated with increased systemic vascular resistance. Placentae from patients with preeclampsia have reduced levels of endothelial nitric oxide synthase (eNOS) and, thus, less nitric oxide (NO). Syncytiotrophoblast extracellular vesicles (STBEV), comprising microvesicles (STBMV) and exosomes, carry signals from the syncytiotrophoblast to the mother. We hypothesized that STBEV-bound eNOS (STBEV-eNOS), capable of producing NO,...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1161/hypertensionaha.117.09321

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Obstetrics & Gynaecology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Obstetrics & Gynaecology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Obstetrics & Gynaecology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Social Sciences Division
Department:
Said Business School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Obstetrics & Gynaecology
Role:
Author
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Publisher:
American Heart Association Publisher's website
Journal:
Hypertension Journal website
Volume:
70
Issue:
2
Pages:
372-381
Publication date:
2017-05-05
Acceptance date:
2017-06-12
DOI:
EISSN:
1524-4563
ISSN:
0194-911X
Pubs id:
pubs:700705
URN:
uri:600bfabe-8563-483d-875f-97b69c7f6e74
UUID:
uuid:600bfabe-8563-483d-875f-97b69c7f6e74
Local pid:
pubs:700705

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