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Role of immunoproteasomes in cross-presentation.

Abstract:

The evidence that proteasomes are involved in the processing of cross-presented proteins is indirect and based on the in vitro use of proteasome inhibitors. It remains, therefore, unclear whether cross-presentation of MHC class I peptide epitopes can occur entirely within phagolysosomes or whether it requires proteasome degradation. To address this question, we studied in vivo cross-presentation of an immunoproteasome-dependent epitope. First, we demonstrated that generation of the immunodomi...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.177.2.983

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Journal:
Journal of Immunology
Volume:
177
Issue:
2
Pages:
983-990
Publication date:
2006-07-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Source identifiers:
7126

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