Bioinformatics analysis of estrogen-responsive genes

Journal article

Abstract:: Estrogen is a steroid hormone that plays critical roles in a myriad of intracellular pathways. The expression of many genes is regulated through the steroid hormone receptors ESR1 and ESR2. These bind to DNA and modulate the expression of target genes. Identification of estrogen target genes is greatly facilitated by the use of transcriptomic methods, such as RNA-seq and expression microarrays, and chromatin immunoprecipitation with massively parallel sequencing (ChIP-seq). Combining transcriptomic and ChIP-seq data enables a distinction to be drawn between direct and indirect estrogen target genes. This chapter discusses some methods of identifying estrogen target genes that do not require any expertise in programming languages or complex bioinformatics.

Files:: 10.1007%2F978-1-4939-3127-9_4.pdf

(Preview, pdf, 1.3MB, Terms of use)

Keywords:: bioinformatics

transcriptomics

gene targets

ChIP-seq

estrogen
Pubs id:: pubs:574642
UUID:: uuid:5fff987b-1289-4dd4-a5d9-dcb3b3755fbf
Local pid:: pubs:574642
Source identifiers:: 574642
Deposit date:: 2015-11-22

Copyright holder:: Adam E. Handel
Notes:: Copyright © 2016 The Authors.
This chapter is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, duplication, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

If you are the owner of this record, you can report an update to it here: Report update to this record