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Mobile elements drive recombination hotspots in the core genome of Staphylococcus aureus

Abstract:

Horizontal gene transfer is an important driver of bacterial evolution, but genetic exchange in the core genome of clonal species, including the major pathogen Staphylococcus aureus, is incompletely understood. Here we reveal widespread homologous recombination in S. aureus at the species level, in contrast to its near-complete absence between closely related strains. We discover a patchwork of hotspots and coldspots at fine scales falling against a backdrop of broad-scale trends in rate vari...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/ncomms4956

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Department:
St Johns College
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Author
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Department:
Oxford, MSD, Primary Care, Primary Care Health Sciences
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Author
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Publisher:
Nature Publications Publisher's website
Journal:
Nature Communications Journal website
Volume:
5
Pages:
Article 3956
Publication date:
2014-05-23
Acceptance date:
2014-04-24
DOI:
ISSN:
2041-1723
Pubs id:
pubs:465923
URN:
uri:5ffaac82-0f77-4a5b-9cdd-accd5fbbe370
UUID:
uuid:5ffaac82-0f77-4a5b-9cdd-accd5fbbe370
Local pid:
pubs:465923

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