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Common variants in maturity-onset diabetes of the young genes and future risk of type 2 diabetes.

Abstract:

OBJECTIVE: Mutations in the hepatocyte nuclear factor (HNF)-1alpha, HNF-4alpha, glucokinase (GCK), and HNF-1beta genes cause maturity-onset diabetes of the young (MODY), but it is not known whether common variants in these genes predict future type 2 diabetes. RESEARCH DESIGN AND METHODS: We tested 14 previously associated polymorphisms in HNF-1alpha, HNF-4alpha, GCK, and HNF-1beta for association with type 2 diabetes-related traits and future risk of type 2 diabetes in 2,293 individuals fro...

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Publication status:
Published

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Publisher copy:
10.2337/db06-1464

Authors


Holmkvist, J More by this author
Almgren, P More by this author
Lyssenko, V More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Eriksson, KF More by this author
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Journal:
Diabetes
Volume:
57
Issue:
6
Pages:
1738-1744
Publication date:
2008-06-05
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
URN:
uuid:5ff9184c-6f82-497d-9f59-116548c5731b
Source identifiers:
10531
Local pid:
pubs:10531

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