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Population pharmacokinetics of artemether, dihydroartemisinin and lumefantrine in Rwandese pregnant women treated for uncomplicated Plasmodium falciparum malaria

Abstract:

The artemisinin-based combination therapy artemether-lumefantrine is commonly used in pregnant malaria patients. However, the effect of pregnancy-related changes on exposure is unclear and pregnancy has been associated with decreased efficacy in previous studies. This study aimed to characterize the population pharmacokinetics of artemether, its active metabolite dihydroartemisinin, and lumefantrine in 22 Rwandese pregnant women of second (n=11) and third trimester (n=11) with uncomplicated P...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/aac.00518-18

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Publisher:
American Society for Microbiology Publisher's website
Journal:
Antimicrobial Agents and Chemotherapy Journal website
Volume:
62
Issue:
10
Article number:
e00518-18
Publication date:
2018-09-24
Acceptance date:
2018-07-30
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
Pmid:
30061282
Source identifiers:
896702
Language:
English
Keywords:
Pubs id:
pubs:896702
UUID:
uuid:5feac2e1-3bba-4a73-b523-5d676d59693c
Local pid:
pubs:896702
Deposit date:
2018-09-03

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