Journal article icon

Journal article

Population pharmacokinetics of artemether, dihydroartemisinin and lumefantrine in Rwandese pregnant women treated for uncomplicated Plasmodium falciparum malaria

Abstract:

The artemisinin-based combination therapy artemether-lumefantrine is commonly used in pregnant malaria patients. However, the effect of pregnancy-related changes on exposure is unclear and pregnancy has been associated with decreased efficacy in previous studies. This study aimed to characterize the population pharmacokinetics of artemether, its active metabolite dihydroartemisinin, and lumefantrine in 22 Rwandese pregnant women of second (n=11) and third trimester (n=11) with uncomplicated P...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1128/aac.00518-18

Authors


Expand authors...
Publisher:
American Society for Microbiology Publisher's website
Journal:
Antimicrobial Agents and Chemotherapy Journal website
Volume:
62
Issue:
10
Pages:
Article: e00518-18
Publication date:
2018-09-24
Acceptance date:
2018-07-30
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
Pubs id:
pubs:896702
URN:
uri:5feac2e1-3bba-4a73-b523-5d676d59693c
UUID:
uuid:5feac2e1-3bba-4a73-b523-5d676d59693c
Local pid:
pubs:896702

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP