Intrapatient escape in the A*0201-restricted epitope SLYNTVATL drives evolution of human immunodeficiency virus type 1 at the population level.

Journal article

The hypothesis that the intrapatient emergence of cytotoxic T-lymphocyte escape variants contributes to the evolution of human immunodeficiency virus type 1 at the population (interpatient) level was tested using the HLA-A*0201-restricted gag p17 epitope SLYNTVATL. Using a simple experimental design, we investigated the evolutionary processes operating within this epitope among patients while compensating for the confounding influence of intrapatient natural selection. Using this approach, we revealed a pattern of A*0201-driven escape within patients, followed by the sustained transmission of these escape variants among patients irrespective of their HLA type.

Authors: Edwards, C; Pfafferott, K; Goulder, P; Phillips, R; Holmes, E

• Publication status: Published
• Journal: Journal of virology
• Volume: 79
• Issue: 14
• Pages: 9363-9366
• Publication date: 2005-07-01
• DOI: 10.1128/jvi.79.14.9363-9366.2005
• EISSN: 1098-5514
• ISSN: 0022-538X
• Language: English
• Keywords: Amino Acid Sequence; Acquired Immunodeficiency Syndrome; Epitopes, T-Lymphocyte; HLA-A Antigens; Humans; HIV-1; Selection, Genetic; T-Lymphocytes, Cytotoxic; Molecular Sequence Data