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Randomized controlled trial of levamisole hydrochloride as adjunctive therapy in severe falciparum malaria with high parasitemia.

Abstract:

BACKGROUND: Cytoadherence and sequestration of erythrocytes containing mature stages of Plasmodium falciparum are central to the pathogenesis of severe malaria. The oral anthelminthic drug levamisole inhibits cytoadherence in vitro and reduces sequestration of late-stage parasites in uncomplicated falciparum malaria treated with quinine. METHODS: Fifty-six adult patients with severe malaria and high parasitemia admitted to a referral hospital in Bangladesh were randomized to receive a single ...

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Publication status:
Published

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Publisher copy:
10.1093/infdis/jit410

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Journal:
The Journal of infectious diseases
Volume:
209
Issue:
1
Pages:
120-129
Publication date:
2014-01-05
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:5f7c156a-28c2-456f-9e76-f417743ce00d
Source identifiers:
418527
Local pid:
pubs:418527

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