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Functional significance of factor H binding to Neisseria meningitidis.

Abstract:

Neisseria meningitidis is an important cause of septicemia and meningitis. To cause disease, the bacterium must successfully survive in the bloodstream where it has to avoid being killed by host innate immune mechanisms, particularly the complement system. A number of pathogenic microbes bind factor H (fH), the negative regulator of the alternative pathway of complement activation, to promote their survival in vivo. In this study, we show that N. meningitidis binds fH to its surface. Binding ...

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Publication status:
Published

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Authors


Schneider, MC More by this author
Feavers, I More by this author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
176
Issue:
12
Pages:
7566-7575
Publication date:
2006-06-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:5f546028-7e14-4e22-836f-45fa8108288e
Source identifiers:
246454
Local pid:
pubs:246454

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