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Functional significance of factor H binding to Neisseria meningitidis.

Abstract:

Neisseria meningitidis is an important cause of septicemia and meningitis. To cause disease, the bacterium must successfully survive in the bloodstream where it has to avoid being killed by host innate immune mechanisms, particularly the complement system. A number of pathogenic microbes bind factor H (fH), the negative regulator of the alternative pathway of complement activation, to promote their survival in vivo. In this study, we show that N. meningitidis binds fH to its surface. Binding ...

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Publication status:
Published

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Journal:
Journal of Immunology
Volume:
176
Issue:
12
Pages:
7566-7575
Publication date:
2006-06-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Source identifiers:
246454

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