- Abstract:
-
The immunosuppressive microenvironment in tumors hampers the induction of antitumor immunity by vaccines or immunotherapies. Toll-like receptor (TLR) ligands have the potential to treat tumors, but they can exert a mixture of positive and negative effects on inflammation in the tumor microenvironment. In this study, we show that specific small molecule inhibitors of phosphoinositide 3-kinase (PI3K) relieve immunosuppression to heighten the proinflammatory effects of TLR ligands that support a...
Expand abstract - Publisher copy:
- 10.1158/0008-5472.can-11-0307
-
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- Journal:
- Cancer research
- Volume:
- 72
- Issue:
- 3
- Pages:
- 581-591
- Publication date:
- 2012-02-05
- DOI:
- EISSN:
-
1538-7445
- ISSN:
-
0008-5472
- URN:
-
uuid:5eecbb7a-731a-4516-89a0-b4effb1d37b5
- Source identifiers:
-
480332
- Local pid:
- pubs:480332
- Language:
- English
- Keywords:
- Copyright date:
- 2012
Journal article
Immunotherapy with PI3K inhibitor and Toll-like receptor agonist induces IFN-γ+IL-17+ polyfunctional T cells that mediate rejection of murine tumors.
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