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Immunotherapy with PI3K inhibitor and Toll-like receptor agonist induces IFN-γ+IL-17+ polyfunctional T cells that mediate rejection of murine tumors.

Abstract:

The immunosuppressive microenvironment in tumors hampers the induction of antitumor immunity by vaccines or immunotherapies. Toll-like receptor (TLR) ligands have the potential to treat tumors, but they can exert a mixture of positive and negative effects on inflammation in the tumor microenvironment. In this study, we show that specific small molecule inhibitors of phosphoinositide 3-kinase (PI3K) relieve immunosuppression to heighten the proinflammatory effects of TLR ligands that support a...

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Journal:
Cancer research
Volume:
72
Issue:
3
Pages:
581-591
Publication date:
2012-02-05
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:5eecbb7a-731a-4516-89a0-b4effb1d37b5
Source identifiers:
480332
Local pid:
pubs:480332

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