Recognition of influenza virus proteins by cytotoxic T lymphocytes.

Journal article

Recombinant DNA techniques have been used to express the proteins of influenza virus individually. Target cells expressing single viral proteins were then used to identify the molecules recognized by cytotoxic T lymphocytes (CTLS). Results have shown that, contrary to expectation, the majority of the proteins recognized by class I major histocompatibility complex-restricted CTLS are not transmembrane glycoproteins. Experiments with deletion mutants of the nucleoprotein (NP) gene showed that t...

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Authors: Townsend, A; Bastin, J; Bodmer, H; Brownlee, G; Davey, J

• Publication status: Published
• Journal: Philosophical transactions of the Royal Society of London. Series B, Biological sciences
• Volume: 323
• Issue: 1217
• Pages: 527-533
• Publication date: 1989-06-01
• DOI: 10.1098/rstb.1989.0032
• EISSN: 1471-2970
• ISSN: 0962-8436
• Language: English
• Keywords: Epitopes; Viral Proteins; Antigens, Viral; Orthomyxoviridae; Transfection; T-Lymphocytes, Cytotoxic; L Cells (Cell Line); Antigen-Antibody Reactions; Mice; Animals