Immunopathology of autoantibody-associated encephalitides: clues for pathogenesis.

Journal article

Classical paraneoplastic encephalitis syndromes with 'onconeural' antibodies directed to intracellular antigens, and the recently described paraneoplastic or non-paraneoplastic encephalitides and antibodies against both neural surface antigens (voltage-gated potassium channel-complexes, N-methyl-d-aspartate receptors) and intracellular antigens (glutamic acid decarboxylase-65), constitute an increasingly recognized group of immune-mediated brain diseases. Evidence for specific immune mechanis...

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Authors: Bien, C; Vincent, A; Barnett, M; Becker, A; Blümcke, I

• Publication status: Published
• Journal: Brain : a journal of neurology
• Volume: 135
• Issue: Pt 5
• Pages: 1622-1638
• Publication date: 2012-05-01
• DOI: 10.1093/brain/aws082
• EISSN: 1460-2156
• ISSN: 0006-8950
• Language: English
• Keywords: Phosphopyruvate Hydratase; Antigens, Neoplasm; In Situ Nick-End Labeling; Male; Glutamate Decarboxylase; Nerve Tissue Proteins; Electroencephalography; Autoantibodies; Humans; Hu Paraneoplastic Encephalomyelitis Antigens; Magnetic Resonance Imaging; Potassium Channels, Voltage-Gated; Cell Death; Microscopy, Confocal; Antigens, CD; Autopsy; Microtubule-Associated Proteins; Encephalitis; Aged; Adult; Receptors, N-Methyl-D-Aspartate; T-Lymphocytes; Brain; Statistics, Nonparametric; Female; Middle Aged